Natural History of Histologically-proven Alcohol Related Liver Disease: A systematic review

In this study we systematically gathered all the published data regarding the natural history of alcohol related liver disease in people who had a liver biopsy to define the prevalence of the disease, the annual risk of progression to cirrhosis and the annual risks of death at each stage of the disease.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research

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Researchers at Cleveland Clinic have discovered a relationship between IBD and non-alcoholic liver disease, postulating that immune factors are involved in both the intestinal and liver lesions (see:Studies Reveal Heightened Liver Disease Rates in IBD Patients Immune-mediated factors may be involved). Below is an excerpt from the article but make note of the reference to the use of Explorsys, a research tool owned by IBM:...Cleveland Clinic researchers and their collaborators have found that patients with inflammatory bowel disease (IBD) experience higher rates of nonalcoholic fatty liver disease, nonalcoholic steatohepati...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Diagnostics Electronic Health Record (EHR) Healthcare Information Technology Healthcare Innovations Medical Research Predictive Analytics Preventive Medicine Public Health Source Type: blogs
CONCLUSIONS: The mortality was high in these severely ill patients, even when they received optimum supportive therapy in the ICU. The finding that the SOFA score and age best predicted mortality shows that the increased mortality was caused mainly by insufficiency of organs other than the liver. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 31315795 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
Abstract Alcoholic liver disease (ALD) is one of the major causes of chronic liver disease worldwide. Currently, no successful treatments are available for ALD. The pathogenesis of ALD is characterized as simple steatosis, fibrosis, cirrhosis, alcoholic hepatitis (AH), and eventually hepatocellular carcinoma (HCC). Autophagy is a highly conserved intracellular catabolic process, which aims at recycling cellular components and removing damaged organelles in response to starvation and stresses. Therefore, autophagy is considered as an important cellular adaptive and survival mechanism under various pathophysiologica...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
Conclusions: Serum lipid parameters were significantly lower in the cirrhotics than in the healthy normal group. Thus, studies of lipid profile may guide us in the prognosis and treatment of alcoholic cirrhosis in the near future. PMID: 31311213 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 24% of the global adult population. NAFLD is a major risk factor for the development of cirrhosis and hepatocellular carcinoma, as well as being...
Source: Clinical Epigenetics - Category: Research Authors: Tags: Review Source Type: research
In this issue, Srivastava et al. evaluated a pathway for the management of patients with non-alcoholic fatty liver disease (NAFLD), using blood tests to stratify patients in primary care in order to improve detection of cases of advanced fibrosis and cirrhosis. They studied 3,000 patients seen in primary care using a 2-step algorithm combining the use of FIB-4 followed by the ELF ™ test if required. Use of this approach detected 5-fold more cases of advanced fibrosis and cirrhosis. Unnecessary referrals from primary care to secondary care fell by 70–80%.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Desk Source Type: research
This is so far the first meta ‐analysis about TM6SF2 polymorphisms and chronic liver disease. Our pooled analyses suggested that rs58542926 polymorphism was significantly associated with chronic liver disease in both Asians and Caucasians. Future investigations are warranted to explore potential roles of other TM6SF2 polymorph isms in the development of chronic liver disease. AbstractBackgroundSome genetic association studies tried to investigate potential associations of transmembrane 6 superfamily member 2 (TM6SF2) polymorphisms with chronic liver disease. However, the results of these studies were not consistent. Thus...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
The recent epidemic in chronic liver disease is related to the burden of Non-Alcoholic Fatty Liver Disease (NAFLD), paralleling the worldwide increase of obesity. [1] NAFLD is a complex condition related to metabolic derangements in insulin resistance (IR), but in a subset of patients the liver becomes the target of multiple hits leading to Non-Alcoholic SteatoHepatitis (NASH), the histological phenotype that may progressively develop liver fibrosis, cirrhosis and possibly hepatocellular carcinoma.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Conclusions: ARFI elastography is a noninvasive, reliable, and repeatable diagnostic test for grading of liver fibrosis. It performs better than the biochemical indices to differentiate severe fibrosis and cirrhosis of liver.
Source: Indian Journal of Radiology and Imaging - Category: Radiology Authors: Source Type: research
Chronic and excessive alcohol consumption causes nearly half of liver cirrhosis-associated mortality in the United States, but there remains no effective treatment for the underlying liver disorder [1]. An early stage of alcohol-related liver disease (ALD), which is featured as simple hepatic steatosis, is reversible; however, chronic and excessive alcohol consumption can lead to progressive steatohepatitis (ASH) and fibrosis, and in some cases, the disease further progresses to cirrhosis and even hepatocellular carcinoma [2,3].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
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