Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture.

CONCLUSIONS: BMSCs from SLE patients are heterogeneous. A subgroup of SLE BMSC is distinguished from other SLE BMSC and from controls by increased levels of mRNAs induced by type I interferons. This subgroup of SLE patients had increased levels of IFNβ in vivo.
PMID: 31153744 [PubMed - as supplied by publisher]

Source: Cytokine - May 28, 2019 Category: Molecular Biology Authors: Gao L, OConnell M, Allen M, Liesveld J, McDavid A, Anolik JH, Looney RJ Tags: Cytokine Source Type: research