Of mice and men: Incretin actions in the central nervous system

Incretins have risen to the forefront of therapies for obesity and related metabolic complications, primarily because of their efficacy and relatively few side effects. Importantly, their efficacy in altering energy balance and decreasing body weight is apparently through actions in the central nervous system (CNS); the latter may have implications beyond obesity per se, i.e. in other disease states associated with obesity including CNS-related disorders. Here, we first describe the role of the CNS in energy homeostasis and then the current state of knowledge in terms of incretins ’ physiology, pathophysiology and efficacy in preclinical and clinical studies.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research