In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation [Psychological and Cognitive Sciences]

Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) to compare with...

Source: Proceedings of the National Academy of Sciences - June 3, 2019 Category: Science Authors: Margaret T. Davis, Ansel Hillmer, Sophie E. Holmes, Robert H. Pietrzak, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo Angarita-Africano, Richard E. Carson, John H. Krystal, Irina Esterlis Tags: Biological Sciences Source Type: research