Could boosting the gut microbiome be the secret to healthier older age?
(Babraham Institute) Fecal transplants from young to aged mice can stimulate the gut microbiome and revive the gut immune system, a study by immunologists at the Babraham Institute, Cambridge, UK, has shown. The study, published in Nature Communications, suggest that the gut microbiome could be a target for the treatment of a range of age-associated symptoms to facilitate healthy ageing.
AbstractAplastic anemia (AA) has been reported to be associated with inflammatory bowel disease (IBD), but mostly with ulcerative colitis (UC). Little is known about the associations between AA and Crohn ’s disease (CD). We aim to determine the portraits of patients with AA-CD. Among a total of 657 patients with CD registered in Xijing Hospital of Digestive Diseases IBD center from January 2008 to October 2018, the patients diagnosed with concurrent AA were reviewed. Clinical presentation, medical history, endoscopic features, response to treatment, and prognosis in this set of patients were collected. Six male patie...
AbstractIncidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%;p
Pioneer UK surgeon Sir Terence English says adapted organs could transform treatmentAdapted pig hearts could be transplanted into patients within three years, according to a report citing the surgeon who pioneered heart transplantation in the UK.On the 40th anniversary of the first successful heart transplant, Sir Terence Englishtold The Sunday Telegraph that his protege from that operation would try to replace a human kidney with a pig ’s this year.Continue reading...
Keith Castle was the first UK heart recipient to live for more than five years afterwards.
Leukemia, Published online: 19 August 2019; doi:10.1038/s41375-019-0544-3Haploidentical vs. unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia in first complete remission: on behalf of the ALWP of the EBMT
Leukemia, Published online: 19 August 2019; doi:10.1038/s41375-019-0539-0A simplified frailty scale predicts outcomes in transplant-ineligible patients with newly diagnosed multiple myeloma treated in the FIRST (MM-020) trial
AbstractMHC class I-related chain A (MICA) is one of the major ligands for natural killer group 2 member D (NKG2D), which is an activating NK receptor. MICA is expressed on the surface of human epithelial tumor cells, and its shedding from tumor cells leads to immunosuppression. To activate immune response in the tumor microenvironment, we designed an anti-VEGFR2 –MICA bispecific antibody (JZC01), consisting of MICA and an anti-VEGFR2 single chain antibody fragment (JZC00) and explored its potential anti-tumor activity. JZC01 targeted vascular endothelial growth factor receptor 2 (VEGFR2) and inhibited tumorigenesis ...
Ganesh S PaiInternational Journal of Trichology 2019 11(4):143-143 Perhaps the best solution for hair loss is a little bit of philosophy and a lot of humor. Endless trips to trichologists, hair potions and lotions hardly prevent the reluctant march to baldness. Unless of course, the patient agrees to a hair transplant.