MRI Results Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: The COMP-ACT MRI Substudy.
CONCLUSION: In a subset of patients who achieved low disease activity with TCZ + MTX, MRI changes were minimal in intra-articular inflammation and damage measures in patients who discontinued MTX vs those who continued TCZ + MTX. PMID: 31154414 [PubMed - as supplied by publisher]
CONCLUSION: These data show that cartilage damage can be localized and quantified in the hand joints of RA patients by T2 mapping. Furthermore, ACPA and RF positivity as well as disease duration appear to be the crucial factors influencing cartilage damage. PMID: 31416926 [PubMed - as supplied by publisher]
Conclusion: BI has a very strong possibility of CMJ compression, while AAS and pannus formation have a high proportion in CMJ compression. Hence bilateral wrist joint erosion can be used as an indicator for the timing of screening test for cervical involvement. We suggest the early recommendation of cervical spine examination for the diagnosis of cervical involvement in order to prevent morbidity and mortality. PMID: 31392874 [PubMed - as supplied by publisher]
Authors: Zabotti A, Finzel S, Baraliakos X, Aouad K, Ziade N, Iagnocco A Abstract There is growing evidence that the development of rheumatoid arthritis (RA) is a multistep process. The European League Against Rheumatism (EULAR) identified different phases before the onset of RA, from the presence of genetic and environmental risk factors for RA, towards clinically suspected arthralgia and undifferentiated arthritis. Currently, a new definition of "window of opportunity" is emerging; this states that the window could even lie in preclinical phase of RA, preceding diagnosis or fulfillment of classification...
AbstractObjectiveRheumatoid arthritis (RA) patients with comorbid fibromyalgia (FM) manifest alterations in brain connectivity synonymous with central sensitization. Here we consider how peripheral inflammation, the principal nociceptive stimulus in RA, interacts with brain connectivity in RA patients with comorbid FM.MethodsRA patients with (FM+, n=27) and without (FM ‐, n=27) comorbid FM completed functional connectivity magnetic resonance imaging. Seed to whole‐brain functional connectivity analyses were conducted using left mid/posterior insula and left inferior parietal lobule (IPL) seeds, regions previously linke...
CONCLUSION: EMM could fit the DCE-MRI data of hand and wrist synovitis. AUC30 obtained from the uptake phase of the kinetic curve as well as A, β and Tpeak obtained throughout the kinetic curve might be effective to predict the clinical disease activity. PMID: 31292313 [PubMed - as supplied by publisher]
To the Editor Treat-to-target strategies using disease activity scores are the cornerstone of rheumatoid arthritis (RA) treatment. Dr M øller-Bisgaard and colleagues compared a conventional treat-to-target strategy with a strategy that also incorporated absence of inflammation on magnetic resonance imaging (MRI). The MRI-guided treat-to-target strategy resulted in similar remission rates and percentages of patients without radiogra phic progression. However, in an exploratory analysis, 46% of the MRI-guided group had used biologics compared with 2% in the conventional strategy group.
CONCLUSION: Synovitis and triquetral synovitis were the most prevalent lesion in three-studied phases. This could suggest the triquetrum as the first morphological site to be affected by RA; so it's assessment should be considered in the RA evaluation when it´s clinically suspected. PMID: 31300634 [PubMed - as supplied by publisher]
ConclusionThe results indicate normal pain sensitivity and cerebral pain processing in RA for non-affected sites, while the increased sensitivity at inflamed joints indicate peripheral/spinal sensitization. Brain imaging data suggest that disease-relevant pain processing in RA is marked by aberrations and a failed initiation of cortical top-down regulation.
CONCLUSION: The results indicate normal pain sensitivity and cerebral pain processing in RA for non-affected sites, while the increased sensitivity at inflamed joints indicate peripheral/spinal sensitization. Brain imaging data suggest that disease-relevant pain processing in RA is marked by aberrations and a failed initiation of cortical top-down regulation. PMID: 31228612 [PubMed - as supplied by publisher]
CONCLUSION: Dynamic contrast-enhanced magnetic resonance imaging using a 4D angiography sequence for the atlantodental region in patients with rheumatoid arthritis for quantitative and qualitative assessment of synovial volume and perfusion characteristics is technically feasible. PMID: 31169411 [PubMed - as supplied by publisher]