Nipah virus resurfaces in India's Kerala after killing 17 last year
The deadly brain-damaging Nipah virus has resurfaced in the southern Indian state of Kerala a year after it killed 17 people, state officials said on Tuesday.
This article will summarize current mechanistic insight into F-mediated membrane fusion and examine the contribution of structural information to the development of small-molecule F inhibitors. Implications are outlined for future drug target selection and rational drug engineering strategies.
This article describes elements of design of such unit (e.g., space, infection control, waste disposal, safety of healthcare workers, partners to be involved in design and plan) which can be adapted to the context of either a new construction or makeshift construction on top of an existing structure. In view of a potential epidemic of COVID-19, specific requirements to handle it are also given. PMID: 32202258 [PubMed - as supplied by publisher]
As the world grapples with the COVID-19 pandemic, some experts say India — a country of more than 1.3 billion people — likely has many more cases than the conservative numbers currently being reported. The outbreak of the new coronavirus, which causes COVID-19, began in China and has since infected more than 124,000 people across more than 110 countries and territories around the world. More than 4,500 people worldwide have died after being infected with COVID-19. India has conducted nearly 5,000 COVID-19 tests so far, according to the World Health Organization, which says that the “country is responding ...
The northern side of Chatuchak Weekend Market feels a bit like Noah has hit hard times and decided to offload the entire contents of his Ark. In wooden cages, bright-plumed fighting cocks squawk and peck. Around the corner are snakes in plastic takeout containers, prices scrawled on them in sharpie. Hairless squirrel kits snooze in a pile as a meerkat and giant iguana gaze on. A pygmy monkey leaps about with a furious scowl, perhaps indignant at the 30,000 baht ($950) price tag fixed to his enclosure. Across the narrow alleyway, a lynx prowls restlessly within its cage. “He’s 250,000 baht [$7,900],” says ...
Research in the last decade has uncovered many new paramyxoviruses, airborne agents that cause epidemic diseases in animals including humans. Most paramyxoviruses enter epithelial cells of the airway using sialic acid as a receptor and cause only mild disease. However, others cross the epithelial barrier and cause more severe disease. For some of these viruses, the host receptors have been identified, and the mechanisms of cell entry have been elucidated. The tetrameric attachment proteins of paramyxoviruses have vastly different binding affinities for their cognate receptors, which they contact through different binding s...
Authors: Zainal A ’Bidin, Farahana Nabilah / Shamsudin, Rosnah / Mohd Basri, Mohd Salahuddin / Mohd Dom, Zanariah
Sunil Kumar RainaJournal of Global Infectious Diseases 2020 12(1):1-2
Conclusion: The rapid spread of infection uncovered the miserable state of health care system in implementing infection control measures. The case fatality and the socio-economic burden warrant developing appropriate treatments, vaccines and diagnostics.
The monoclonal antibody m102.4, being developed to prevent and treat Hendra and Nipah virus infection, was well tolerated and safe in a first-in-human study.Reuters Health Information
[IPS] Colombo, Sri Lanka -In the wake of the latest coronavirus outbreak, movie buffs are drawing an eerie parallel with the film Contagion, a 2011 thriller based on a lethal airborne virus called Nipah and how the world's medical community battled to find a cure for the pandemic.