474 underwater vs. conventonal endoscopic  resection of non-diminutive non-pedunculated colorectal lesions: a prospective randomized controlled trial

Incomplete resection of colorectal neoplasia decreases the efficacy of colonoscopy and contributes to post-colonoscopy colorectal cancer. Conventional endoscopic resection (CR) of polyps, performed in a gas-distended colon, is the current standard, but incomplete resection rates (IRR) of approximately 3-25% for non-diminutive (>5mm) non-pedunculated lesions are reported. Underwater endoscopic resection (UR), a novel technique utilizing advantages of water-aided colonoscopy, may help reduce IRR.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research

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With more colorectal cancer screening&large polyp removal, delayed post-polypectomy ulcer bleeds (PPUB) are increasing. Risk factors are right colon, sessile configuration, EMR removal, bleeding during polypectomy,&resumption of anti-coagulants&/or dual anti-platelet drugs. Prophylactic clip closure of PPU ’s is reported to be safe but does not reduce delayed PPUB nor is it cost effective. In our studies of patients hospitalized with delayed PPUB, all had ulcers, most with stigmata&arterial blood flow detected by Doppler endoscopic probe (DEP).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
Cosmeri Rizzato1, Javier Torres2, Elena Kasamatsu3, Margarita Camorlinga-Ponce2, Maria Mercedes Bravo4, Federico Canzian5 and Ikuko Kato6* 1Department of Translation Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy 2Unidad de Investigación en Enfermedades Infecciosas, Unidades Médicas de Alta Especialidad Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico 3Instituto de Investigaciones en Ciencias de la Salud, National University of Asunción, Asunción, Paraguay 4Grupo de Investigación en Biología del C&aacut...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusions The current review reports recent epidemiological and experimental data supporting the bright future of dietary polyphenols as chemopreventive, anti-inflammatory, immunomodulatory, and anticancer agents in CRC (Figure 1). The polyphenol-rich diet not only may represent a chemopreventive treatment but also has important function on immune system by promoting symbiont and commensal bacterial populations, increases reciprocal interaction between host and microbiota which in turn have important effects on immune function Evidence underlines the use of polyphenols as sensitizers of chemo/radiotherapies paving the w...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
RESUMEN: La Poliposis Adenomatosa Familiar (PAF) es un s índrome hereditario autosómico dominante causado por la mutación del gen APC. En su forma clásica se desarrollan más de 100 pólipos adenomatosos intestinales que progresan a cáncer colorrectal en casi el 100% de los casos no tratados. Dentro de las manifestaciones extracolónicas de PAF, se e ncuentran las maxilofaciales, como: osteomas y alteraciones dentales, que pueden preceder por años al desarrollo de poliposis colónica. A pesar de que en Chile hay estudios de PAF y cáncer de colon, son ...
Source: Revista clinica de periodoncia, implantologia y rehabilitacion oral - Category: Dentistry Source Type: research
Purpose of review Colonoscopy is recognizably, the best colon cancer prevention test, provided the quality of the preparation is adequate for detection of precancerous polyps but also allowing for accurate identification of margins, thereby facilitating complete endoscopic resection. As there are many aspects effecting colon prep outcomes, it is timely to review new standards for optimizing outcomes, including product selection based on patient demographics. Recent findings New national guidelines have set a minimum quality threshold for adequacy and also defined a split day delivery for oral options as the “sta...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: LARGE INTESTINE: Edited by Eamonn M.M. Quigley Source Type: research
Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. Recent studies suggest a benefit of endoscopic devices attached to the distal tip of the colonoscope for improving the ADR. This work is the first three arm randomized controlled trial comparing standard colonoscopy with Endocuff and Cap.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
Adenoma detection rate (ADR) is inversely related to the risk of interval colorectal cancer and is a primary measure of colonoscopist quality. Multiple studies have shown improved ADR with use of assistive devices, including Endocuff and AmplifEYE. Similarly, use of water exchange or water immersion is associated with improved polyp detection, particularly proximal sessile serrated adenomas, with a trend toward higher detection of adenomas throughout the colon. The potential additive effects of these techniques remain untested.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
Abstract AIM: To assess the cleansing efficacy and safety of a new Colon capsule endoscopy (CCE) bowel preparation regimen. METHODS: This was a multicenter, prospective, randomized, controlled study comparing two CCE regimens. Subjects were asymptomatic and average risk for colorectal cancer. The second generation CCE system (PillCam® COLON 2; Medtronic, Yoqneam, Israel) was utilized. Preparation regimens differed in the 1st and 2nd boosts with the Study regimen using oral sulfate solution (89 mL) with diatrizoate meglumine and diatrizoate sodium solution ("diatrizoate solution") (boost 1 = 60 m...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
The Growing Toll of Our Ever-Expanding WaistlinesBy  JANE E. BRODY NOV. 13, 2017Paul Rogers I hope you ’re not chomping on a bagel or, worse, a doughnut while you read about what is probably the most serious public health irony of the last half century in this country: As one major killer — smoking — declined, another rose precipitously to take its place: obesity.Many cancer deaths were averted after millions quit lighting up, but they are now rising because even greater numbers are unable to keep their waistlines in check.Today, obesity and smoking remain the two leading causes of pre...
Source: Dr Portnay - Category: Cardiology Authors: Source Type: blogs
The objectives were to evaluate the relationship between the expression of these hormone receptors and adenoma-carcinoma progression, CRC stage and overall survival. We studied 120 A.C. Camargo Cancer Center patients diagnosed with either FAP-associated or spontaneous adenomatous polyps or CRC to determine the immunohistochemical expression levels of estrogen receptor (ER)-α, ER-β and the progesterone and androgen receptors (480 analyses). The ER-β expression levels differed between the groups: the group with FAP polyps had lower ER-β expression than that of the sporadic polyp group. With transformatio...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
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