The Link Among Neurological Diseases: Extracellular Vesicles as a Possible Brain Injury Footprint.

The Link Among Neurological Diseases: Extracellular Vesicles as a Possible Brain Injury Footprint. Neurosignals. 2019;27(1):25-39 Authors: Ciccocioppo F, Lanuti P, Centonze D, Miscia S, Marchisio M Abstract Extracellular vesicles (EVs), referred as membranous vesicles released into body fluids from all cell types, represent a novel model to explain some aspects of the inter-cellular cross talk. It has been demonstrated that the EVs modify the phenotype of target cells, acting through a large spectrum of mechanisms. In the central nervous system, the EVs are responsible of the wide range of physiological processes required for normal brain function and neuronal support, such as immune signaling, cellular proliferation, differentiation, and senescence. Growing evidences link the EV functions to the pathogenic machinery of the neurological diseases, contributing to the disease progression and spreading. Extracellular vesicles are involved in the brain injury by multimodal ways; they propagate inflammation across the blood brain barrier (BBB), mediate neuroprotection and modulate regenerative processes. For these reasons, extracellular vesicles represent a promising biomarker in neurological disorders as well as an interesting starting point for the development of novel therapeutic strategies. Herein, we review the role of the EVs in the pathogenesis of neurological disease, discussing their potential clinical applications. PMID: 31150575 [PubMed - in p...
Source: Neuro-Signals - Category: Neurology Authors: Tags: Neurosignals Source Type: research

Related Links:

.
Source: Anxiety, Stress and Coping - Category: Psychiatry & Psychology Authors: Source Type: research
.
Source: Educational Psychologist - Category: Psychiatry & Psychology Authors: Source Type: research
Bayer submits application to European Medicines Agency for pre-filled syringe to administer eye medication Eylea®mehr ...
Source: Bayer IR Newsfeed: Events - Category: Pharmaceuticals Source Type: news
Conclusion: New lesions at the reference MRI in terms of number and topography increase the risk of radiological disease activity during the follow up. PMID: 31959078 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
MiR-29a-3p/NID1 axis regulates pulmonary fibrosis induced by TGF-β1. Panminerva Med. 2020 Jan 20;: Authors: Lin L, Qu W, Li Y, Zhu H, Jiang W PMID: 31961112 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Zhang J, Guo Y, Jia T, Guo H, Meng F, Xue S PMID: 31961111 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Gao J, Zhao G, Wang P, Li S, Wang X, Zhao H PMID: 31961110 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Wang X, Wen Y, Xue L, Lu R, Tang H, Gao N, Zhang J, Xue Q PMID: 31961109 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Wang P, Xue L, Wang L, Tang H, Lv C, Xue Q PMID: 31961108 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Luan J, Liu Y, Liu H, Wang Z PMID: 31961114 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
More News: Brain | Neurology