Next-generation paclitaxel-nanoparticle formulation for pancreatic cancer treatment

In this study, we demonstrate the therapeutic efficacy of a novel PLGA-PTX nanoformulation (PPNPs). This system shows efficacy both in vitro and in vivo. Specifically, nanoindentation studies show an increased rigidity of PPNPs-treated pancreatic cancer cells, indicating reduced metastatic potential as confirmed with additional results herein (proliferation, colony formation, invasion, migration, cell cycle arrest, apoptosis induction). In vivo results indicate successful reduction in tumor growth, metastasis, and EMT markers in chemo-naïve and chemo-exposed orthotopic xenograft mice, suggesting that PPNPs may be a next-generation paclitaxel nanoformulation for PanCa treatment.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research