Acute liver failure associated with influenza A virus infection: an autopsy case report.
Acute liver failure associated with influenza A virus infection: an autopsy case report. Jpn J Infect Dis. 2019 May 31;: Authors: Nonaka K, Matsuda Y, Kakizaki M, Takakuma S, Hamamatsu A, Sakashita Y, Matsubara T, Murayama S, Ishiwata T, Yamanaka N, Itabashi M, Takei T, Nakajima N, Hasegawa H, Arai T Abstract An 84-year-old man with chronic renal failure, anemia, and diabetes was admitted for hemodialysis initiation. His vital signs were stable until the eighteenth hospital day, before having an influenza A virus infection. Three days later, he died of septic shock with severe liver impairment. His leukocyte count, prothrombin time (PT-INR), and liver enzymes, such as AST and ALT, were significantly increased. Hypercytokinemia was also observed. Autopsy revealed bilateral diffuse pneumonia with neutrophil infiltration. The liver showed extensive centrilobular hepatocyte necrosis. Immunohistochemistry for influenza A nucleoprotein was positive in the ciliated columnar epithelium of the bronchi and negative in the trachea, lungs, and liver. Hypoxic hepatitis is characterized by an abrupt and massive increase in aminotransferase levels (more than 20 times of the upper normal limit) due to the anoxic centrilobular hepatocyte necrosis. The occurrence of hypoxic hepatitis requires a pre-existing, chronic condition, such as anemia, causing less oxygen supply to the liver, followed by an acute drop in hepatic oxygen supply, such as septic shock. Therefore, this ...
TYPE 2 diabetes is a common condition which affects a person ’s blood sugar level control, and left untreated, serious health complications can occur. One way to control blood sugar levels could be to eat a vegetable native to the Mediterranean.
This study's results suggest that both combination and sequential therapy of pd-FVIIa/FX and other bypassing agents are well tolerated and effective for the control of perioperative bleeding in haemophilia patients with high-responding inhibitors.
Protein S Tokushima (p.Lys196Glu) and two protein C gene variants (p.Arg189Trp, p.Lys193del) are hereditary thrombophilia in Japanese and Chinese populations, respectively; however, their diagnosis by plasma analyses is difficult because of the type II deficiency phenotype. Three gene variant genotypes were examined in young Japanese women (n = 231). Plasma total protein S activity and total protein S antigen levels were measured using a total protein S assay system, protein C and protein S activities by clot-based methods, and protein C and free protein S antigen levels by latex agglutination methods. protein S Tokush...
Conclusions: Solithromycin concentrations in DBS were similar to those measured in LPS and did not require correction for hematocrit or protein binding.
ConclusionsThe effect of therapy directed toward EGFR mutation or EML4 –ALK fusion gene might obscure the significant prognostic difference between M1b and M1c.
ConclusionApalutamide had manageable safety profile, without any DLT or any new safety signals, and favourable efficacy in Japanese mCRPC patients. Thus, it was ascertained to be an adequate dosage regimen in Japanese mCRPC patients.Trial registrationClinicalTrials.gov identifier: NCT02162836.
Publication date: Available online 16 November 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Anil Kumar Singh, Himanshu Pandey, Pramod W. Ramteke, Shanti Bhushan MishraAbstractUrsolic acid is a pentacyclic carboxylic acid present in medicinal herbs abundantly. There is scientific evidence of important benefits of ursolic acid in metabolism of lipids and glucose, as well as on the body weight and metabolic parameters. However, the hydrophobicity of ursolic acid increases the difficulty in its potential clinical application. The aim of the present study is to develop ursolic acid nanoparticles to enhance ...