Change in arterial tumor perfusion is an early biomarker of lenvatinib efficacy in patients with unresectable hepatocellular carcinoma.

CONCLUSION: CEUS may be useful for the early prediction of tumor response to lenvatinib therapy in patients with unresectable HCC. PMID: 31148907 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research

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610Purpose: In previous research, we identified a new target named α21, which specifically expressed in cancer stem cells (CSCs). And a α21 targeting antibody named 1B50-1 was produced at the same. These α21+ tumor-initiating cells (TICs) with stem cell-like properties, might be the cell of origin for HCC recurrence. The exact mechanism was not known clearly. Herein, we reported the production of novel positron emission tomography (PET) radiotracer 64Cu-NOTA-1B50-1 and explore its feasibility of non-invasively detecting and quantitating of CSCs on hepatocellular carcinoma (HCC). Methods: 1B50-1 antibody w...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology II Source Type: research
Authors: Machida K Abstract Alcohol abuse synergistically heightens the development of the third most deadliest cancer hepatocellular carcinoma (HCC) in patients infected with hepatitis C virus (HCV). Ectopically expressed TLR4 promotes liver tumorigenesis in alcohol-fed HCV Ns5a or Core transgenic mice. CD133+/CD49f + tumor-initiating stem cell-like cells (TICs) isolated from these models are tumorigenic have p53 degradation via phosphorylation of the protective protein NUMB and its dissociation from p53 by the oncoprotein TBC1D15. Nutrient deprivation reduces overexpressed TBC1D15 in TICs via autophagy-...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
MicroRNA-31 suppresses the self-renewal capability of α2δ1(+) liver tumor-initiating cells by targeting ISL1. Oncotarget. 2017 Oct 20;8(50):87647-87657 Authors: Zhang Y, Zhao W, Han H, Li S, Chen D, Zhang Z Abstract Accumulating evidence demonstrates that miRNAs, a class of small non-coding RNAs, are involved in the regulation of tumor-initiating cells (TICs) which are considered to be the origin of cancer development according to the cancer stem cell hypothesis. We have previously identified that miR-31 may play suppressive roles in α2δ1(+) hepatocellular carcinoma (HCC) TICs. ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study, we show that MSC migration to HCC can be effectively inhibited by TACE and γ-secretase inhibitors that stop the activation of EpCAM signaling event. Silencing of EpCAM expression through siRNA and antibody approaches also resulted in impaired MSC migration. By contrast, increase levels of EpICD proteins in HCC cells and HCC mouse xenografts resulted in enhanced MSC migration. Taken together, these findings show that MSC is drawn to the more oncogenic population of HCC, and could potentially serve as a cell-based carrier of therapeutic genes to target EpICD-enriched hepatic tumor cells. PMID: 285528...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
AbstractThe cancer stem cell (CSC) hypothesis has been disproved in many cancers. CSCs may exist in blood cancer, while many epithelial cancers may not have CSCs but tumor-initiating cells (TICs). Several independent studies have provided strong evidence for existence of CSCs in brain, skin, and colon cancers (Mani et  al. in Cell 133:704–715,2008, Joseph et  al. in Cancer Cell 13:129–140,2008, Reya et  al. in Nature 414:105–111,2001), while the CSC hypothesis remains controversial (Magee et  al. in Cancer Cell 21:283–296,2012). Liver TICs have bipotential to give rise to two dif...
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Conclusions Contrast-enhanced US with phenylephrine stress may be helpful in differentiating BPE from residual tumor after RF ablation in hepatocellular carcinoma.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
This study provides insights into the mechanisms of NANOG-mediated generation of TICs, tumorigenesis, and chemoresistance through reprogramming of mitochondrial metabolism. PMID: 26724859 [PubMed - as supplied by publisher]
Source: Cell Metabolism - Category: Cytology Authors: Tags: Cell Metab Source Type: research
ConclusionsOn‐site TICs showed its usefulness in reducing the number of cores required for adequate diagnostic materials. In the meantime, TICs accurately provided preliminary interpretations, especially in adequate malignant carcinoma cases. Diagn. Cytopathol. 2015. © 2015 Wiley Periodicals, Inc.
Source: Diagnostic Cytopathology - Category: Pathology Authors: Tags: Original Article Source Type: research
Obesity and alcohol consumption contribute to steatohepatitis, which increases risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs). Mice Hepatocytes that express HCV-NS5A in liver upregulate expression of Toll-like receptor-4 (TLR4), and develop liver tumors containing tumor-initiating stem-like cells (TICs) that express NANOG. We investigated whether the TLR4 signals to NANOG to promote development of TICs and tumorigenesis in mice placed on Western diet high in cholesterol and saturated fat (HCFD).
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Obesity and alcohol consumption contribute to steatohepatitis, which increases the risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs). Mouse hepatocytes that express HCV-NS5A in liver up-regulate the expression of Toll-like receptor 4 (TLR4), and develop liver tumors containing tumor-initiating stem-like cells (TICs) that express NANOG. We investigated whether the TLR4 signals to NANOG to promote the development of TICs and tumorigenesis in mice placed on a Western diet high in cholesterol and saturated fat (HCFD).
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Original Research Source Type: research
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