Prescription Medications for the Treatment of Insomnia and Risk of Suicide Attempt: a Comparative Safety Study

Conclusions and RelevanceCompared to zolpidem, hazard of suicide attempt was 61% higher with trazodone (<  200 mg). No significant differences in suicide attempt risk were identified between benzodiazepines or sedating antihistamines and zolpidem, respectively. These findings provide the first comparative effectiveness evidence against the use of trazodone for insomnia.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research