Prescription Medications for the Treatment of Insomnia and Risk of Suicide Attempt: a Comparative Safety Study

AbstractImportanceGuidelines for the pharmacological treatment of chronic insomnia in adults recognize that trazodone and other off-label medications are commonly prescribed despite poor evidence. The Department of Veterans Health Affairs (VA) fills high volumes of inexpensive, over-the-counter sedating antihistamines and older antidepressants in addition to benzodiazepines and zolpidem. Yet little is known about the comparative safety of these agents with regard to suicidal behavior.ObjectivesTo assess the comparative effectiveness of the safety of medications routinely used to treat insomnia in VA.DesignComparative effectiveness using propensity score-matched samples.SettingVA.ParticipantsVA patients without any history of suicidal ideation or behavior 12  months prior to first exposure.ExposuresVA formularies and data were used to identify prescriptions for insomnia. Agents accounting for at least 1% of total insomnia fill volume were
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research

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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Self-Esteem Achievement Body Language Confidence Impostor Syndrome Self Image Source Type: blogs
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Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Rui Yan1, ShiWan Tao1, HaiYan Liu1, Yu Chen1, JiaBo Shi1, YuYin Yang1, RongXin Zhu1, ZhiJian Yao1,2* and Qing Lu3,4*1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China2Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing, China3School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China4Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaBackground: Major depressive disorders often involve somatic symptoms and have been found to have fundamental differences from non-somatic depressi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
With all the news media accounts and reports from governmental health organizations about the opioid epidemic, including the 70,237 drug overdose deaths in 2017, a newly emerging threat is gaining attention: use and misuse of benzodiazepines, opioid drugs and Z-drugs. Specifically, combining these three drugs can create a deadly combination that snuffs out lives. Benzodiazepine Overdose Deaths on the Rise Benzodiazepines, a class of sedative narcotic drugs including Xanax and Valium used to treat anxiety, insomnia and other disorders and classified as Schedule IV under the Controlled Substances Act by the Drug Enforcement ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Substance Abuse Suicide Source Type: news
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Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Addiction Treatment and Program Resources Alcoholism Anxiety Behavioral Addictions Depression Depression Treatment Drug Rehab Information Drug Treatment Dual Diagnosis and Eating Disorder Treatment Sober Source Type: blogs
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Drugs and Supplements Health Source Type: blogs
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Creativity Grief and Loss Peer Support Self-Help Bipolar Disorder bipolar mania Depressive Episode Manic Episode Source Type: blogs
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review anxiety disorder depression insomnia psychiatric disorder psychosis schizophrenia sleep disorder Source Type: research
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Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Consensus recommendations Source Type: research
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