miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes

We previously found that high-mobility group box protein 1 (HMGB1) promoted cell proliferation, migration, invasion, and autophagy in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), but little is k...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research

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Abstract Multiple cytokines play a pivotal role in the pathogenesis of Rheumatoid Arthritis by inducing intracellular signaling and it is known that the members of the Janus kinase (JAK) family are essential for such signal transduction. Janus kinase 3 is a tyrosine kinase that belongs to the Janus family of kinases. Drugs targeting JAK3 in the treatment of Rheumatoid arthritis is relevant. Therefore, it is of interest to design suitable inhibitors for JAK3 dimer using molecular docking with Molegro Virtual Docker. The compound possessing the highest affinity score is subjected to virtual screening to retrieve inh...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Bruno Kusznir Vitturi, Bruno Azeredo Coutinho Nascimento, Beatriz Rizkallah Alves, Felipe Sobolewski Carneiro de Campos, Dawton Yukito TorigoeAbstractBackgroundNeurological manifestations of Rheumatoid Arthritis (RA) are usually uncommon. However, a number of recent studies have reported that the burden of cognitive impairment in RA could be significant. We sought to explore the prevalence and clinical predictors of cognitive impairment in persons with RA.MethodsThis is a cross-sectional case-control study with patients with...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionsWhile many intervention regimens in other studies are administered prior to disease onset in animal models, the current study involves delivery of the potential therapeutic after disease onset. Based on the findings, vamorolone may offer an efficacious, yet safer alternative to conventional steroidal compounds in the treatment of rheumatoid arthritis and other inflammatory diseases.
Source: Inflammation Research - Category: Research Source Type: research
This study explored the role of central sensitization (CS) pain in patients with various rheumatic diseases using the CS inventory (CSI).MethodsA total of 193 patients of mean age 50.72  ± 9.65 years were included; they were divided into four different groups in terms of their rheumatic diseases. Patients with rheumatoid arthritis (RA), spondyloarthropathy (SpA), osteoarthritis (OA), and fibromyalgia syndrome (FMS) were evaluated in tertiary care rheumatology/pain medicine se ttings. Disease duration and activity, the Bath Ankylosing Spondylitis Disease Activity Index, the Disease Activity Score-2...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionThis systematic review and conventional meta-analysis demonstrated the overall similarity of the long-term efficacy and safety of biosimilar rituximab to those of originator rituximab in RA and NHL patients by combining direct evidence from head-to-head trials.PROSPERO registration No. CRD42019125138.
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
Abstract OBJECTIVES: Evaluate the relationship between arthritis diagnosis in those over 50 and exposure to extreme air pollution in utero or infancy (
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
Findings show a dose - or frequency - dependent association; all antibiotic classes linked to higher odds for RA
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Pharmacy, Pulmonology, Rheumatology, Journal, Source Type: news
ConclusionGEN inhibits IL-6–induced VEGF expression and angiogenesis partially through the JAK2/STAT3 pathway in RA, which has provided a novel insight into the antiangiogenic activity of GEN in RA.The translational potential of this articleOur study provides scientific guidance for the clinical translational research of GEN in the RA treatment.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
FRIDAY, Aug. 23, 2019 -- Antibiotic prescriptions are associated with a higher risk of rheumatoid arthritis (RA), according to a study published online Aug. 7 in BMC Medicine. Alyshah Abdul Sultan, Ph.D., from Keele University in the United Kingdom,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Strand V, Shah R, Atzinger C, Zhou J, Clewell J, Ganguli A, Tundia N Abstract Objective: Determine healthcare resource utilization (HCRU) and associated costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA). Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large U.S. commercial insurance database identified new cases of stiffness/fatigue among newly diagnosed patients. Study patients had ≥2 medical claims for RA ≥45 days apart, continuous insurance coverage ≥12 mont...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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