High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate

Conclusions:
Diabetic HDL carries higher level of S1P compared with normal HDL, which has the potential to contribute to protective effects on endothelial cells by inducing COX-2 expression and PGI-2 release. These findings provide a new insight of S1P function in T2DM patients, possibly leading to a new therapeutic target.

Source: Cardiovascular Diabetology - January 30, 2013 Category: Cardiology Authors: Xunliang TongHui PengDonghui LiuLiang JiChenguang NiuJun RenBing PanJianying HuLemin ZhengYining Huang Source Type: research