Relationship Between Chronic Hepatitis B Virus Infection and Nature Killer Cells

Viral Immunology, Ahead of Print.
Source: Viral Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Authors: Păcurar D, Dijmărescu I, Dijmărescu A, Pavelescu M, Andronie M, Becheanu C Abstract Chronic viral hepatitis has been incriminated for inducing autoimmune events, but it is a known fact that interferon-based therapies also promote autoimmunity. We conducted an observational prospective study which included 114 pediatric patients with chronic viral hepatitis B and C. The patients were divided in 2 groups, the first group consisted of treatment-naive patients; the second group included patients who had received interferon-based therapy. We aimed to determine whether the ones who received treatment are more...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Condition:   Chronic Hepatitis b Interventions:   Drug: Entecavir;   Drug: Tenofovir Disoproxil Fumarate;   Drug: Tenofovir Alafenamide Sponsor:   Third Affiliated Hospital, Sun Yat-Sen University Recruiting
Source: - Category: Research Source Type: clinical trials
Conclusion: Results revealed a significant association between elevated APRI and HCC development in patients with chronic hepatitis, suggesting that APRI might serve as a valuable predictor for HCC risk in patients with chronic hepatitis. PMID: 31814857 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Plan outlines efforts to intensify ongoing HBV research.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
In this study, we aim to determine the hepatic pathological changes in HBV DNA-negative chronic Hepatitis B (CHB) patients after 12-month antiviral therapy.
Source: Infectious Agents and Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
AbstractBackground.Microvascular invasion (MVI) is associated with poor postoperative survival outcomes in patients with hepatocellular carcinoma (HCC). An Eastern Hepatobiliary Surgery Hospital (EHBH) MVI scoring system was established to predict prognosis in patients with HCC with MVI after R0 liver resection (LR) and to supplement the most commonly used classification systems.Materials and Methods.Patients with HCC with MVI who underwent R0 LR as an initial therapy were included. The EHBH‐MVI score was developed from a retrospective cohort from 2003 to 2009 to form the training cohort. The variables associated with ov...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Hepatobiliary Source Type: research
Conclusion.Our study suggests that the post‐treatment serum IL‐6 level, rather than pretreatment or dynamic changes of IL‐6, serves as a powerful predictor for tumor response. These findings provide evidence to help discriminate between patients who will particularly benefit from TACE and those who require more personalized therapeutic regimens and rigorous surveillance.Implications for Practice.Transarterial chemoembolization (TACE) is a major therapeutic regimen for advanced hepatocellular carcinoma. Thus, identification of early practical markers of tumor response to TACE is of high importance. This study indicate...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Hepatobiliary, Radiation Oncology, Cancer Diagnostics and Molecular Pathology Source Type: research
AbstractThe aim of this work is to reveal impacts of a nuclear power plant on environmental radioactivity and public health since commission in the South China Sea. After long-term monitoring, it turns out that radioactivity in ambient air environment, water, soil, sweet potato, rice, chicken, lamb, butterfish and prawn meet demands of national environment protection standards and food safety standards in China. After 6 years ’ statistic check of local residents, the top tree diseases before and after the plant’s commission remained pulmonary tuberculosis, hand-foot-and-mouth disease, and hepatitis B. Incidence...
Source: Journal of Radioanalytical and Nuclear Chemistry - Category: Nuclear Medicine Source Type: research
This study investigated the interaction of synthesized immunogenic ‘a’ determinant (aD) region of hepatitis B virus surface antigen (HBsAg) with PAMAM G4 and anti-HBsAg antibody, as a potential bio-nanogate for anti-HBsAg detection. The aD peptide fused with maltose binding protein (MBP), was confirmed with Western blotting. Nano-Differential Scanning Fluorimetry (nano-DSF) study revealed that the interaction of MBP-aD with anti-HBsAg indicated a higher thermal stability as compared to its interaction with PAMAM G4. Electrochemical impedance spectroscopy showed that a higher binding constant of MBP-aD interacti...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Predictive value of plasmacytoid dendritic cells and Toll-like receptor-9 regarding the treatment efficacy of interferon-α in HBeAg-positive chronic hepatitis B patients. Exp Ther Med. 2019 Dec;18(6):4541-4546 Authors: Chen Y, Yang JE, Tang JM, Mao QG, Zheng QZ, Zheng Y Abstract Hepatitis B virus (HBV) infection represents a public health threat and a challenge for the medical community. Untimely treatment may lead to liver cirrhosis and even liver cancer. At present, the major treatment for hepatitis B e antigen (HBeAg)-positive chronic hepatitis B patients includes administration of interferon-...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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