Selection and Radiolabeling of Bicyclam Analogues for Imaging CXCR4 Expression in Gliomas (GBM) and primary CNS lymphoma (PCNSL)

Conclusions: The absence of CXCR4 tumor imaging in the two brain tumor models with 76Br HZ270 1 is largely due to the hydrophilicity of the radiolabeled bicyclam analogues (based on the measured octanol/water partition coefficient, LogP), in contrast to the structure based estimate of LogP and to the presence of an intact BBB and BTB in the animal intracranial tumor models.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiochemistry & amp; Chelation Posters Source Type: research