Comparison of [ 18F]D3FSP([18F]P16-129) and [18F] AV45 in Alzheimers Disease

Conclusions: In this small sample of 6 AD subjects, there were no substantial differences between [18F]D3FSP vs. [18F]AV45 but, 50% of the subjects did have slightly higher global cortical SUVR with [18F]D3FSP vs. [18F]AV45. Although all had a clinical diagnosis of AD, some of the subjects had only moderate quantitative uptake using the [18F]AV45 criteria. Visual inspection suggests [18F]D3FSP vs. [18F]AV45 may have some subtle differences in clinical readings and there may be quantitative differences in some individual cases but a larger population is needed with more severe patients before concluding the potential improved diagnostic value of [18F]D3FSP. Support by Five Eleven Pharma Inc.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Wong, D., Kuwabara, H., Kitzmiller, K., Nandi, A., Brinson, Z., George, N., Alexoff, D., Brasic, J., Fan, H., Holt, D., Gapasin, L., Roberts, J., Lesniak, W., Ye, W., Zhou, Y., Dannals, R., Kung, H. Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research