Extended structure-activity study of anilino quinazoline-based EGFR tyrosine kinase inhibitors and the 18F-FDGPET/CT imaging for monitoring the therapeutic efficacy in non-small cell lung cancer

Conclusions: In conclusion,F-MPG or H-MPGhave good drug-like properties, better anti-tumor activity, andless liver damage after PEGylated compared with PD153035 which providing solid evidence for future clinical trials. The betterantitumor activityof F-MPG or H-MPGin vitroand in vivomay be related to the extended structure-activity. On the one hand, the modified drugs with lower lipophilicity and better water solubility reduced the clearance by hepatobiliary metabolism and improved the targeting with tumor. On the other hand, it may be related to self-assembly to nanoparticles after structure modified, while the EPR effect indirectly increased drug distribution in tumor.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) Posters Source Type: research