PET targeting molecular imaging of human epidermal growth factor receptor-positive tumors labeled with Affibody molecules

Conclusions: [68Ga]Ga-NOTA-ZEGFR:1907is a novel PET tracer for tumor with overexpression of EGFR, which has the ability to identify tumors with high and low EGFR expression in vivo, promising to achieve clinical transformation.References: [1]. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature. 1985;313(5998):144-7. [2] Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Critical Reviews in Oncology/hematology. 1995;19(3):183-232. [3] Sato JD, Kawamoto T, Le AD, Mendelsohn J, Polikoff J, Sato GH. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Molecular Biology & Medicine. 1983;1(5):511.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) Posters Source Type: research