Upregulation of Nicotinic Acetylcholinergic Receptors in Human Lung Adenocarcinomas

Conclusions: This preliminary study shows upregulation of nicotinic receptors in human non-small cell lung adenocarcinomas. This is consistent with our findings in A/J mice lung tumor model using [18F]nifene PET (in vivo tumor/nontumor = 1.5-2.0; ex vivo = 4). The human specimens are being tested with [18F]nifene (for α4β2) and [18F]ASEM (for α7) in order to test for consistency with the above findings and for potential translation to human PET studies of lung cancer. Relationship between tumor grade and α7 nAChR upregulation will require more specimens.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) Posters Source Type: research