Relationship between 99mTc-3PRGD2 SPECT/CT imaging and tumor angiogenesis in non-small cell lung cancer

In this study, we investigated the association between 99mTc-3PRGD2 SPECT/CT imaging and tumor angiogenesis by analyzing images and postoperative pathological findings in patients with non-small cell lung cancer(NSCLC). Methods: Retrospectively collected data from 56 patients who underwent 99mTc-3PRGD2 SPECT/CT imaging in our department from July 2015 to December 2016 and were able to obtain postoperative pathological block within seven days. Calculate the ratio of the highest uptake value of the lesion (T) to the contralateral normal lung (N) uptake value, and determine the T/N ratio of 99mTc-3PRGD2 SPECT/CT imaging for the diagnosis of benign and malignant lung lesions according to pathological results as the gold standard. Immunohistochemical analysis of integrin αvβ3 expression was performed in 96 lesions with pathological block of 56 patients. Statistical analysis was performed to evaluate the relationship between the T/N ratio of 99mTc-3PRGD2 SPECT/CT imaging and the expression level of integrin αvβ3 in NSCLC.And our research was approved by the Hospital Ethics Committee. Results: According to the pathological results, the ROC curve was drawn according to the T/N ratio of the two groups of patients with malignant lung lesions and benign lesions. The area under the ROC curve was 0.682 (P=0.035<0.05), and ROC analysis suggested an T/N cut-off value of 2.07 to differentiate between malignant lesions and benign lesions. At this time, the sensitivity...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer Posters Source Type: research