Detection of Metabolic Changes using Hyperpolarized 13C MRI in a Negative 18F-FDG PET Rat Brain Cancer Model

Conclusions: The present study demonstrates that hyperpolarized 13C MRS potentially can be used to identify and characterize gliomas that are 18F-FDG negative. The Lac/Bic imaging marker is interesting because it reports on the ratio between increased glycolysis (Warburg effect) and the more ATP favorable oxidative phosphorylation inside the cells3. Further histological analysis will be performed to get better understanding how the metabolic differences correlate with the proliferative state of the tumor. Acknowledgements NIH grants R01CA176836, R01EB019018, P41EB01589, S10OD012283, S10OD018130-01 GE HealthcareLucas Foundation References 1. Druckrey H, Ivankovic S, Preussmann R. Nature 210:1378-1379, 1966 2. Jang T, Sathy B, Hsu YH, Merchant M, Recht B, Chang C, Recht L. J Neurosurg108:782-90, 20083. 3. Park JM, Spielman D, Josan S, Jang T, Merchant M, Hurd RE, Mayer D and Recht LD. NMR Biomed. 29(5):650-9, 2016
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Multimodality and Nonradioactive Probes Posters Source Type: research