Applications of PET in Radiation Oncology

1139Introduction: Thoracic malignancies are among the most common malignancies diagnosed both in the United States and worldwide. Radiation therapy (RT) plays an important role in the treatment of thoracic malignancies. Depending on the primary disease site and tumor stage, RT can be used as monotherapy, or as part of multimodality therapy for curative intent, or for palliative reduction of advanced disease. In fact, more than 50% of all patients with thoracic malignancies will receive RT as part of their multidisciplinary care. 18F-Fluorodeoxyglucose positron emission tomography (PET) is commonly used for initial cancer diagnosis, disease staging, outcome prognostication, radiation therapy (RT) planning, treatment response assessment, and detection of recurrent disease. In radiation oncology, PET plays a major role in RT target volume delineation, treatment response monitoring, evaluation for radiation-induced toxicities, and verification of radiation dose delivery. As advanced techniques such as intensity-modulated radiation therapy (IMRT) and proton therapy have increased in utilization, positron emission tomography/computed tomography (PET/CT) have played increasingly critical roles in the target delineation of tumors for radiation oncologists delivering conformal treatments, especially when treating thoracic malignancies. In RT, improvement in target localization permits reduction of tumor contour margins, consequently reducing the volume of normal tissues irradiated. Fu...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibit Posters Source Type: research

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Publication date: Available online 21 October 2019Source: Life SciencesAuthor(s): Yu Dong, Tao Xu, Shouping Zhong, Bo Wang, Huimin Zhang, Xin Wang, Peng Wang, Guangshun Li, Shuanying YangAbstractAimsCircular RNAs (circRNAs) acted as key regulators in the development of various human tumors. Our present study aimed to investigate the role and molecular mechanism of circ_0076305 in regulating cisplatin (DDP) resistance of non-small cell lung cancer (NSCLC).Main methodsUsing RT-qPCR, the expressions of circ_0076305 in NSCLC tissues and cells (A549, H1650, A549/DDP, H1650/DDP) were measured. Through loss-of-function and overex...
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSIONWe report a case of laparoscopic hepatectomy for liver metastasis of lung LCNEC. It is suggested that surgical resection for solitary distant metastasis of LCNEC may improve prognosis.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 21 October 2019Source: European Journal of RadiologyAuthor(s): Xueru Zhu, Xiaoyang Li, Hengle Gu, Wen Yu, Xiaolong FuAbstractPurposeTo analyze radiation-induced lung injury (RIL) after stereotactic body radiotherapy (SBRT) of lung cancer and the subsequent clinical problems.Methods106 lung cancer patients treated with SBRT were included, their computed tomography (CT) scans were reviewed. Late injury pattern was classified by Koening’s, radiologist’ diagnosis reports for RIL was reviewed. Logistic regression was used to analyze the predictive model of injury pattern, which was...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Researchers from the University of Leeds and University of Exeter have called for X-rays, which cost £25 a pop, to be scrapped as the first-line test for lung cancer (file)
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: OnMedica Latest News - Category: UK Health Source Type: news
In conclusion, AFAP1-AS1 promoted chemotherapy resistance by supressing miR-139-5p expression and promoting RRM2/EGFR/AKT signaling pathway in NSCLC cells.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Crizotinib was effective and well tolerated in Chinese patients with ALK-positive, advanced NSCLC in real-world clinical practice. For patients without BBM, crizotinib as first-line therapy can lead to a longer PFS than second-or later line therapy. CBPD plus local therapy after 1st PD beyond crizotinib is feasible and effective in clinical routine practice.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
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