Radiosynthesis and evaluation of [18F]FMTP: A potential COX-2 PET ligand

Conclusions: We report a facile radiolabeling procedure for the COX-2 ligand [18F]FMTP, in excellent purity and molar activity. [18F]FMTP showed moderate uptake and specific binding in COX-2 positive BxPC3 cells. MicroPET imaging in mice showed BBB penetration and fast washout in brain due to low concentration of COX-2 in normal brain. In vitro binding to COX-2 and the BBB permeability of [18F]FMTP indicate that it may be a useful PET tracer for in vivo imaging of COX-2 in neuroinflammation. Research support: Diane Goldberg Foundation (NYSPI/CUMC), NCATS UL1TR001873 (Reilly) Irving Institute/CTSA Translational Therapeutics Accelerator

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Prabhakaran, J., KUMAR, D., Simpson, N., Kim, J., Castrillon, J., Molotkov, A., Doubrovin, M., Mann, J., Mintz, A. Tags: Preclinical Probes for Neuroimaging Posters Source Type: research