First-in-human PET imaging study using [68Ga]-Folate tracer, [68Ga]EC2115

Conclusions: Development of novel approaches for detecting activated macrophages in patients could lead to important advances in studying and treating lung diseases, including COPD. Our studies will develop a novel imaging approach to monitor inflammation in COPD and provide information regarding disease severity and progression. Identifying patients with high levels of macrophage activation could delineate subgroups of patients who would benefit from anti-inflammatory or macrophage-targeted therapies. In addition, measuring macrophage activation in COPD will help to characterize the mechanistic roles of macrophages in this disease.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cohen, A., Douglas, K., Roller, L., Fisher, A., Peterson, T., Liu, F., Nickels, M., Smith, G., Blackwell, T., Manning, H. C. Tags: Outcomes/Infectious Disease/Pulmonary Posters Source Type: research