Novel Derivatives of Anaplastic Lymphoma Kinase Inhibitors: Synthesis, Radiolabeling and Preliminary Biological Studies of Fluoroethyl Analogues of Crizotinib, Alectinib and Ceritinib

Conclusion: These novel fluoroethyl ALK inhibitor analogues show promise for enhanced blood brain barrier penetration and therapeutic potential in the central nervous system (CNS).

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Radaram, B., Pisaneschi, F., Rao, Y., Yang, P., Piwnica-Worms, D., Alauddin, M. Tags: Preclinical Probes for Oncology Posters Source Type: research