F-18 FDG PET/CT for monitoring immunotherapy with PD-1 blockade in patients with advanced melanoma

Conclusions: In this retrospective study of patients with advanced melanoma treated with PD-1 antibodies, tumor response by standard PERCIST was significantly correlated with OS. Modifications of the PERCIST criteria to account for inflammatory lesions did not substantially improve the prognostic value of tumor response on FDG PET. While these results are promising for the use of FDG PET for monitoring immunotherapy, further studies are warranted to understand the impact of the type of immunotherapy and the timing of the FDG PET scans on response assessment. Table1PERCISTCMRPMRSMDPMDtotalimPERCISTCMR1300013PMR02301235SMD025613PMD0012122total132563983
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Sarcoma/ Melanoma Source Type: research