Image-based biomarkers for bone sarcomas using F-18 FDG PET/CT: determination of optimal parameters and their prognostic threshold

Conclusions: We successfully applied a novel algorithm for determination of optimal parameters and their prognostic threshold for not proportionally distributed parameters in contrast to Cox proportional hazard model. Prognostic parameters and their optimal threshold for BS patients in PET/CT varied depending upon histology, with the most promising results being achieved in OS patients. Concerning PET/CT, SUVmax proved to be of prognostic value in all entities. For CT, tumor volume, skewness and solidity proved to be of prognostic value in OS, and skewness and -solidity in ES. Furthermore, in OS, patients our results suggest a synergistic prognostic value of combining PET and CT parameters, which could help in defining patient groups in need of more aggressive adjuvant/neoadjuvant therapy.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Sarcoma/ Melanoma Source Type: research