Imaging PD-L1 expression in tumors following radiotherapy treatment

Conclusions: While the absolute level of 89Zr-Df-atezolizumab accumulation in tumor tissues was low due to the presence of notable sink tissues, significant differences were noted between treated and untreated tissues. PD-L1 imaging may therefore play a unique role for monitoring of treatment efficacy by comparing the dynamics of immune checkpoint expression before, during, and after therapeutic intervention.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Ehlerding, E., Ferreira, C., Jiang, D., KANG, L., Engle, J., McNeel, D., Cai, W. Tags: Preclinical Probes for Oncology II Source Type: research