Cancer screening using 18F-FDG PET/MR in asymptomatic subjects: a Retrospective Study

Conclusions: Based on the findings in this study, we suggest that FDG PET/MR might be an effective cancer screening modality in appropriate combination with other screening modalities. Table 1. Age distribution of subject and cancer detection rate in each age groupAgeNumber of subjects and percentage (%)Number with cancer and detection rate (%)20-2953 (1.90)1(1.49)30-39348(12.46)9(13.43)40-49996(35.65)15(22.39)50-59957(34.25)28(41.79)60-69361(12.92)11(16.42)70-7966(2.36)2(2.99)80 and above13(0.47)1(1.49)total2974 (100)67Table 2. 5 of 12 False positive cases detected by PET/MRNO.AgeSexorganHistological diagnosisMethods of confirmation176FColonadenomatous polypSurgery+ histology244FBreastfibroadenomaSurgery+ histology352FThyroidthyroid adenomaSurgery+ histology431MThyroidthyroid adenomaSurgery+ histology550MThyroidthyroid adenomaSurgery+ histology
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors/ Hematologic Malignancies (Clinical) II Source Type: research

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In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors.The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)2}]. The structures of all mixes were completely portrayed by spectroscopic techniques (1H-NMR, 13C{1H} NMR , IR and elemental and further analyzed by DFT/...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
CONCLUSION: PSs represent a potential tool to treat this form of breast cancer by providing peptides that may be useful in therapy. PMID: 32065785 [PubMed - in process]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
Publication date: Available online 17 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Hombaiah Chandana, B. Madhu, M.R. Narayana MurthyAbstractIntroductionGlobally, cervical cancer is the 4th most common cancer and is one of the leading cancers causing death in India. Cervical cancer is one of those cancers which can be easily prevented by screening women who are aged above 30 years and by vaccinating young girls against HPV. Lack of awareness about cervical cancer makes early detection and timely screening difficult. Awareness about cervical cancer among people will help us to decide on an appropria...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
ConclusionsOur findings support measurement invariance of the EORTC QLQ-C30 in a large sample of patients with hematological malignancies. The results showed that the number of non-invariant items was negligible, suggesting that this questionnaire is a valid and robust measurement tool in patients with hematological malignancies, also for comparisons across groups and time.
Source: Quality of Life Research - Category: Health Management Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Hongying Wang, Weiping TianAbstractMicroRNAs (miRNAs) have been proven to be critical regulators of cancer development. To date, many of them are still in urgent need of characterisation, and role of miR-595 in hepatocellular carcinoma (HCC) remains unknown. To better understand the mechanism of miR-595 in HCC development, a series of experiments were carried out to explore the effects of miR-595 on malignant behaviour in HCC. First, we found that miR-595 was downregulated in HCC tissues and cells and tightly associated w...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Bolin Wang, Zhong Lu, Yan Huang, Tao LinAbstractPurposeNumerous studies have reported the prognostic role of lncRNA-ATB high expression in solid tumours, but its prognostic effect is still uncertain. Therefore, the purpose of this meta-analysis was to further comprehensively verify the prognostic role of the lncRNA-ATB high expression in solid tumours.MethodsA literature search was performed using the electronic platforms to obtain relevant research studies published up to 31 May 2019. Confidence intervals of research end...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Sug Hyung Lee
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionFindings from this study suggest that the SS-PU-SS-PEG micelles could achieve well-controlled triggered drug release in a reduction environment and could therefore improve the antitumor efficacy of osteosarcoma therapies.Translation potential of this articleIn this study we developed PEG-sheddable reduction-sensitive polyurethane micelles (SS-PU-SS-PEG), which were able to achieve well-controlled triggered release of anti-tumor drug Doxorubicin (DOX) in an intracellular reduction environment. DOX-loaded SS-PU-SS-PEG micelles markedly improved the antitumor efficacy in a Saos-2 cells-bearing xenograft tumor model....
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Publication date: Available online 17 February 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Yu-Chuan Lu, Ming-Chieh Kuo, Jian-Hua Hong, Fu-Shan Jaw, Chao-Yuan Huang, Jason Chia-Hsien Cheng, Hsiu-Ni KungBackground/PurposeThe inflammatory milieu has been firmly established to affect cancer progression. However, the connection between natural killer (NK) cells and prostate cancer (PCa) has not been elucidated.MethodsProspective data on NK cell activity (NKA) and NK cell subset distribution patterns were evaluated from 51 patients treated with robot-assisted laparoscopic radical prostatectomy. Whole-blood ...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Conditions:   Microbial Colonization;   Pancreas Cancer;   Pancreas Infection;   Pancreas; Fistula Intervention:   Diagnostic Test: Microbiome evaluation Sponsor:   Azienda Ospedaliera Universitaria Integrata Verona Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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