Safety and efficacy of 3D-printing template combined with CT-guided radioactive Iodine-125 seeds implantation in the treatment of thoracic malignancies: a single-center prospective phase I clinical trial

428Objectives: To clarify the safety and efficacy of radioactive Iodine-125 seeds implantation (RISI) in the treatment of thoracic malignant tumors, and to explore the relationship between different doses of RISI and efficacy and side effects. Materials and Methods: Inclusion criteria: (1) Primary or metastatic tumors of the chest with definite pathological diagnosis; (2) unable or unsuitable for surgery or radiotherapy; (3) tumor diameter 70 score. All patients underwent preoperative planning design, 3D printing template design and printing, CT-guided seeds implantation assisted by template and post-operative dosimetric verification. The patients were followed up regularly after treatment. The main outcome measures were local control rate and toxicity, and the secondary end-point was total survival. Short-term efficacy was evaluated based on RECIST criteria, and toxicity was evaluated based on CTCAE criteria. Statistical methods: Chi-square test was used to compare the rates. Kaplan-Meier method was used to analyze the local control rate and survival rate of patients. Log-rank test was used for univariate analysis and COX regression model was used for multivariate analysis. Results: 41 cases of primary lung cancer and 51 cases of lung metastasis were included in the study. The median diameter of the lesion was 5 cm (1.4-7.0 cm). The median D90 was 142.6 Gy (81-241.8 Gy) obtained by post-operative dosimetric verification. The median follow-up period was 10.7 months (1-36.6 mo...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors/ Hematologic Malignancies (Clinical) I Source Type: research

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