The value of serum MK and Gal-3 in the diagnosis and prediction postoperative metastasis of thyroid cancer

Conclusions: Serum MK and Gal-3 had a some clinical value for identify the benign and malignant thyroid nodules before surgery and predict metastasis before the first 131I treatment in DTC patients after thyroidectomy.Key words :Thyroidneoplasms; Serum MK; Serum Gal-3; Diagnosis, differential; MetastasisTable 1. Serum markers comparisons between three groups before operationGroupMalignancy groupBenign groupControl groupFPNumber231932Age(Y)47.39±11.5248.47±12.7846.00±11.180.280.79MK(pg/mL)385.79±198.62280.63±98.42a,b270.93±104.18a48.400.00[asterisk]Gal-3(ng/mL)2.97±1.451.27±0.40a,b1.05±0.39a5.080.01[asterisk] [asterisk]: P<0.05, a: compare with malignancy group, P<0.05, b: compare with control group, P>0.05. Table 2. Serum markers comparisons between three groups before the first 131I treatment in DTC patients after thyroidectomy operation GroupMetastasis positive groupMetastasis negative groupControl groupF/tPNumber84332Age(Y)40.41±9.5348.41±10.8946.00±11.18MK(A)(pg/mL)489.93±124.69277.41±115.24a,b270.93±104.18a16.670.00[asterisk]Gal-3(A)(ng/mL)2.82±1.511.74±0.66a,b1.05±0.39a11.440.00[asterisk]Tg(ng/mL)176.30±131.9415.10±14.38-4.860.00[asterisk] [asterisk]: P<0.05; a:compare with metastasis positive group, P<0.05, b: compare with control group, P>0.05.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Du, F., Liu, S., Ma, H., Yang, Z., Liu, J., Hu, S., Wu, C., Cheng, Y. Tags: Head and Neck Cancer Source Type: research