Preliminary Investigation of Hypoxia within Tumor Using EPRI, DCE-MRI, and PET-CT with 18F-FMISO to Improve Radiotherapy

Conclusions: Based on this preliminary dataset and low Dice coefficient values between PET and EPR images, we conclude that FMISO does not solely target hypoxia, and if it is to be used as a method of image-guided radiotherapy, it must be corrected by some other relevant physiological parameters, including but not limited to DCE-MRI imaging. Future analysis of this data includes adjusting hypoxia thresholds in PET data by tumor to lung ratio and by SUVmax, and developing spatial regression models for EPR in terms of PET, ktrans, ve, and RSI with better prediction properties. An example of data used for analysis.Subject:691415Tumor Volume (mm3)373612630257EPR Hypoxic Fraction0.08340.1700.2800PET Hypoxic Fraction0.5060.09490.6950.436Dice Coefficient0.2330.1950.2210
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) III Source Type: research