Two stage {micro}PET/CT imaging of TCO-anti-CD11b with a64Cu-NOTA-tetrazine tracer to monitor anti-GBM and lupus nephritis

Conclusions: Anti-GBM and lupus nephritis were both successfully imaged by microPET/CT using a two-stage targeting strategy with the TCO-anti-CD11b/64Cu-NOTA-tetrazine system. Further studies are warranted to optimize these biorthogonal reactants for imaging and organ inflammation in autoimmune diseases. Key Words: CD11b, PET imaging, Copper-64, Pretargeting
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Radiochemistry for Cancer Applications Source Type: research