Imaging Mucociliary Clearance Using F-18 Alumina PET: A Proof in Concept Study

Conclusions: A simple and highly efficient synthesis of [18F]-labeled alumina nanoparticles was developed and the [18F]-labeled alumina nanoparticles show good in vitro stability. The [18F]-labeled alumina nanoparticles were successfully delivered to pig airways via nebulizer or micro-sprayer. Varying the size of the droplets affected the deposition of the radioactivity within the airways. MCC clearance was observed using PET, with most of the clearance occurring within the first few minutes of radiotracer administration.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Abou Alaiwa, M., Hilkin, B., Akurathi, V., Watkins, G., Stoltz, D., Sunderland, J., Welsh, M., Dick, D. Tags: Outcomes/Infectious Disease/Pulmonary II Source Type: research