SPECT/CT Imaging of Intramyocardial Blood Volume with 99mTc-RBC for Detection of Doxorubicin-induced Microvascular Cardiotoxicity in Dogs

Conclusions: Serial SPECT/CT imaging with 99mTc-RBC was able to detect step-wise decrements in IMBV in a progressive, chronic canine model of DOX-induced cardiotoxicity. The application of this method to other cardiovascular diseases and during the administration of chemotherapy agents that primarily influence the microvasculature (e.g. trastuzumab) is needed to realize the full potential of SPECT quantification of IMBV.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Shi, L., Boutagy, N., Feher, A., Wu, J., Greco, K., Sinusas, A., Liu, C. Tags: Cardiovascular Basic Science: Myocardial Perfusion and Flow Quantification Source Type: research