Initial in vivo evaluation of [11C]MPC-6827, a microtubule imaging agent in transgenic mice model of amyotrophic lateral sclerosis

Conclusions: Initial in vivo studies in SOD1[asterisk]G93A mice indicated lower binding of [11C]MPC-6827 in transgenic mice compared to wild types. Our initial evaluations suggest that [11C]MPC-6827 can be a potential radiotracer for imaging ALS and other neurodegenerative disorders in which alteration of microtubule is hypothesized.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Solingapuram Sai, K. K., Milligan, C., Rajagopal, S. A., Prabhakaran, J., Mann, J. J., Mintz, A., KUMAR, D. Tags: Basic Science II (Neurosciences) Source Type: research