Diagnostic Value of Early F-18-FDOPA PET-CT for Initial Staging of Neuroblastoma: A Comparison Study with Delay F-18-FDOPA PET-CT and I-123-MIBG Scintigraphy/SPECT-CT

Conclusions: Early F-18-FDOPA PET-CT displayed higher sensitivity and accuracy than delay F-18-FDOPA PET-CT and I-123-MIBG scintigraphy/SPECT-CT. Furthermore, higher maxSUV on early scan than that of delay scan in true positive lesions means that early F-18-FDOPA PET-CT demonstrated more discrete uptake. We suggest that early F-18-FDOPA PET-CT as a new opportunity for initial staging of neuroblastoma. Lesion-based sensitivity and maxSUV comparison of early, delay F-18-FDOPA PET-CT and I-123-MIBG scinMethods/LocationsEarly F-18-FDOPA PET-CTDelay F-18-FDOPA PET-CTI-123 MIBG scintigraphy and SPECT-CTP-valueTotal100/105 (95.2%)80/105 (76.2%)55/105 (52.4%)<0.001[asterisk]Primary tumor11/11 (100.0%)11/11 (100.0%)10/11 (90.9%)0.357Soft tissue metastasis (lymph node and liver)28/30 (93.3%)24/30 (80.0%)5/30 (16.7%)<0.001[asterisk]Bone/bone marrow metastasis61/64 (95.3%)45/64 (70.3%)40/64 (62.5%)<0.001[asterisk]MaxSUV of both early and delay F-18-FDOPA PET-CT true positive lesions (total)5.2±2.7 (1.3-17.9)3.3±2.1 (0.9-15.3)(-)<0.001[asterisk]MaxSUV of primary tumor5.7±3.4 (2.7-15.2)3.9±3.9 (1.4-15.3)(-)<0.001[asterisk]MaxSUV of soft tissue metastasis3.6±1.2 (1.3-7.0)2.1±0.7 (0.9-3.6)(-)<0.001[asterisk]MaxSUV of bone/bone marrow metastasis5.8±2.9 (1.8-17.9)3.7±1.8 (0.9-10.0)(-)<0.001[asterisk]
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Pediatrics Source Type: research