18F FLT PET predicts cellular proliferation in pediatric brain tumors

156Objectives: Brain tumors are the most common solid tumor in children and are responsible for substantial morbidity and mortality in the pediatric population. [18F] FDG PET/CT has been of limited utility in the evaluation of brain tumors, due to the high level of FDG uptake in the normal brain. Other PET radiopharmaceuticals, such as [18F] FLT, a putative measure of cellular proliferation, have demonstrated promise for the evaluation of brain tumors in adults, but have not been studied systematically in children. The aim of this study is to evaluate the use of [18F] FLT to assess cellular proliferation in pediatric brain tumors. Methods: [18F] FLT PET was performed in 22 pediatric patients (age 6-21 y) in which MRI suggested a newly diagnosed or recurrent brain tumor. Participants were enrolled at Boston Children’s Hospital and five institutions of the Pediatric Brain Tumor Consortium. Study protocols were approved by an IRB at each institution. Informed written consent was obtained. At each institution, [18F] FLT PET or PET/CT was performed on a camera included in a multi-institution validation program. No pre-study preparation was required of participants, and brain PET/CT was performed 30-45 minutes after intravenous administration of 5.2 MBq/kg [F18] FLT. No or minimal uptake was observed in normal brain tissue. PET images were analyzed on a stand-alone workstation (Hermes Medical Systems, Montreal) in a single image analysis core. Image analysis used ROI and VOI ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Pediatrics Source Type: research

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Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Thermochimica Acta - Category: Chemistry Source Type: research
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Source: Polymer - Category: Chemistry Source Type: research
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Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
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Source: Catalysis Today - Category: Chemistry Source Type: research
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Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
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