Induction and repair of DNA double-strand breaks in blood leukocytes of prostate cancer patients during Lu-177-PSMA therapy

Conclusions: In general, we observed a pattern of the time- and absorbed dose-dependent induction and repair of DSB foci during Lu-177-PSMA therapy that is similar to that of other radionuclide therapies [1, 3]. The correlation with clinical findings needs further research in a larger number of patients. References: 1. Eberlein U, Nowak C, Bluemel C et al., Eur J Nucl Med Mol Imaging. 2015;42(11):1739-49. doi:10.1007/s00259-015-3083-9. 2. Eberlein U, Peper M, Fernandez M et al., PLoS One. 2015;10(4):e0123174. doi:10.1371/journal.pone.0123174. 3. Eberlein U, Scherthan H, Bluemel C et al., J Nucl Med. 2016;57(2):173-9. doi:10.2967/jnumed.115.164814.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Schumann, S., Scherthan, H., Lapa, C., Serfling, S., Muhtadi, R., Lassmann, M., Eberlein, U. Tags: Radiopharmaceutical Sciences (RPSC) YIA Symposium Source Type: research