PET imaging of pre-synaptic protein SV2A in Rett syndrome mouse model

Conclusions: These preliminary results reveal decreased uptake of [11C]UCB-J in the Rett syndrome mouse model are consistent with the hypothesis that the loss of Mecp2 gene may result in decreased synaptic density in the cerebral cortex. Studies are ongoing to increase the sample size that may inform future investigation into whether [11C]UCB-J imaging can serve as a valid biomarker in individuals with Rett syndrome.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: DiFilippo, A., Ferreira, C., Engle, J., Barnhart, T., Dong, Q., Chang, Q., Christian, B. Tags: Basic Science I (Neurosciences) Source Type: research