In vivo quantitative mapping of mitochondrial cardiac membrane potential: First in human

Conclusions: We demonstrated for the first time the feasibility of noninvasive, in vivo, quantitative assessment of cardiac T in humans. Quantitative values of T are in good agreement with bench top measurements in isolated mitochondria, cells and Langendorff perfused rat hearts (see Alpert et al, 2018). Currently, there are no methods for direct in vivo assessment of mitochondrial function. In vivo quantification of the mitochondrial function could provide new diagnostic and prognostic information for several cardiac diseases as well as allowing therapy monitoring. Further investigations are required to assess these potential roles. Research Support: P41EB022544 R01HL137230 T32EB013180 Acknowledgments: We thank Marina T. Macdonald-Soccorso and Julia-Ann Scotton for their essential contribution to this project.

Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Pelletier-Galarneau, M., Kim, S. J. W., Petibon, Y., Guehl, N., Ma, C., Han, P., Martineau, P., Normandin, M., El Fakhri, G., Alpert, N. Tags: Cardiovascular YIA Symposium Source Type: research