Hereditary Cancer Syndromes —A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes

Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for multiple extracolonic malignancies. In this second part of a review series on hereditary cancer syndromes, the focus will be to provide guidance on the features and management of the most commonly encountered hereditary colorectal cancers and polyposis conditions including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and hamartomatous polyposis.

Source: Mayo Clinic Proceedings - May 31, 2019 Category: Internal Medicine Authors: N. Jewel Samadder, Noemi Baffy, Karthik V. Giridhar, Fergus J. Couch, Douglas Riegert-Johnson Tags: Thematic review series on precision medicine Source Type: research