Short-term outcomes for lung cancer resection surgery in HIV infection

Conclusions: In a national antiretroviral-era cohort of lung cancer patients undergoing surgical lung resection, short-term outcomes after surgery did not differ significantly by HIV status. Concerns regarding short-term surgical complications should have limited influence on treatment decisions for PWH with lung cancer.
Source: AIDS - Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research

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Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion:In hemodynamically stable patients with chest pain, sinus tachycardia aids in the identification of patients unlikely to have type I MI, especially in those with HR> 120 bpm.
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
No abstract available
Source: AIDS - Category: Infectious Diseases Tags: Errata Source Type: research
AbstractWe aimed to estimate the burden of serious fungal infections in Egypt, currently unknown, based on the size of the populations at risk and available epidemiological data. Data were obtained from the World Health Organization (WHO), the Joint United Nations Programme on HIV/AIDS (UNAIDS), and published reports with clearcut denominators. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology. The population of Egypt in 2011 was ∼82,500,000; 31% children, and 8% women>60  years of age. Amongst about 21.8 million women aged 15&n...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
The objective is to clarify the role of immunodeficiency and pneumonia in elevated lung cancer risk among HIV-infected individuals. Design: Cohort study of HIV-infected and HIV-uninfected adults in a large integrated healthcare system in California during 1996–2011. Methods: We used Poisson models to obtain rate ratios for lung cancer associated with HIV infection, overall and stratified by recent CD4+ cells/μl (HIV-uninfected as reference group), with χ2 tests for trends across CD4+ strata. Fully adjusted models included demographics, cancer risk factors (smoking, drug/alcohol abuse, overweight/obesity), an...
Source: AIDS - Category: Infectious Diseases Tags: Clinical Science: Concise Communication Source Type: research
Conclusions Computed tomography-guided fiducial placement is a feasible and safe technique that allows biopsy at the time of the procedure and aids localization of small pulmonary nodules during video-assisted thoracic surgery.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication March 2016 Source Type: research
This study looked at the risk of influenza pneumonia in those who had received the influenza jab. Out of 2767 patients hospitalised due to pneumonia, 162 (5.9%) had swab confirmed...
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Lung neoplasms, Epidemiologic studies, Vaccination programs, Drugs: infectious diseases, HIV/AIDS, Influenza, Pneumonia (infectious disease), TB and other respiratory infections, Vaccination / immunisation, Lung cancer (oncology), Screening (oncology), As Source Type: research
Abstract Cigarette smoking remains highly prevalent among persons living with human immunodeficiency virus (HIV), estimated to be 40–75 %, and is significantly higher than what is observed among the general population. Health risks of smoking in this population include cardiovascular disease; bacterial pneumonia, chronic obstructive pulmonary disease, and other respiratory conditions; lung cancer and other malignancies; adverse cognitive and neurological outcomes; low birth weight, preterm birth, and small-for-gestational-age infants; and overall mortality. Smokers with HIV now lose more life years to s...
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research
Conclusions: Our data suggest that pulmonary damage and inflammation associated with HIV infection may be causative for the increased risk of lung cancer. Encouraging and assisting younger HIV-infected smokers to quit and to sustain cessation of smoking is imperative to reduce the lung cancer burden in this population.
Source: AIDS - Category: Infectious Diseases Tags: Clinical Science Source Type: research
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