Effects of chemotherapy on placental development and function using in vitro culture of human primary cytotrophoblasts

Discussion The most commonly used chemotherapeutic drugs are well supported in vitro by syncytiotrophoblasts, except for epirubicin, which was very cytotoxic. Chemotherapy perturbed the expression of genes normally upregulated during placental differentiation and angiogenesis but not the expression of the drug transporters. Further studies looking at the effect of combination therapy and the transporter capacities to reject the drugs will be needed to better define the effects of chemotherapy on placental development and function.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research