Astrovirus and the microbiome

Publication date: August 2019Source: Current Opinion in Virology, Volume 37Author(s): Valerie Cortez, Elisa Margolis, Stacey Schultz-CherryAlthough astroviruses are most commonly associated with acute gastrointestinal illness in humans, their ability to infect a broad range of hosts and cause a spectrum of disease makes them widespread and complex pathogens. The precise mechanisms that dictate the course of astrovirus disease have not been studied extensively but are likely driven by multifactorial host–microbe interactions. Recent insights from studies of animal astrovirus infections have revealed both beneficial and detrimental effects for the host. However, further in-depth studies are needed to fully explore the consequences of astrovirus-induced changes in the gut microenvironment as well as the role of the microbiota in astrovirus infection.
Source: Current Opinion in Virology - Category: Virology Source Type: research