Gout, flares, and allopurinol use: a population-based study

There is a paucity of community-based data regarding the prevalence and impact of gout flares as these may often be self-managed. The aim of this study was to determine the prevalence of self-reported gout and...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research

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Publication date: Available online 11 August 2019Source: Journal of Food Composition and AnalysisAuthor(s): Beiwen Wu, Janet M. Roseland, David B. Haytowitz, Pamela R. Pehrsson, Abby G. ErshowAbstractGout, the most common type of inflammatory arthritis and associated with elevated uric acid levels, is a global burden. “Western” dietary habits and lifestyle, and the resulting obesity epidemic, are often blamed for the increased prevalence of gout. Purine intake has shown the biggest dietary impact on uric acid. To manage this situation, data on the purine content of foods are needed. To assess availability and q...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
ObjectiveTo examine whether allopurinol dose escalation to achieve serum urate (SU) target can influence bone erosion or monosodium urate (MSU) crystal deposition, as measured by dual ‐energy computed tomography (DECT) in patients with gout.MethodsWe conducted an imaging study of a 2 ‐year randomized clinical trial that compared immediate allopurinol dose escalation to SU target with conventional dosing for 1 year followed by dose escalation to target, in gout patients who were receiving allopurinol and who had an SU level of ≥0.36 mmoles/liter. DECT scans of feet and radiog raphs of hands and feet were obtained at ...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Authors: Fu Y, Huang QL Abstract Xanthoma is a rare condition mostly caused by hyperlipidemia. The pathogenesis of gout is hyperuricemia, which is caused by a disorder of purine metabolism and/or a decrease in uric acid excretion. Xanthoma combined with gout is very rare. This case report presents magnetic resonance images of a case of xanthoma combined with gout infiltration of the Achilles tendon. PMID: 31384134 [PubMed]
Source: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders - Category: Orthopaedics Tags: Clin Med Insights Arthritis Musculoskelet Disord Source Type: research
This study was aimed at investigating the best compatibility ratio of SMP on hyperuricemia and gouty arthritis and getting better insight of the possible mechanism. Methods. In vitro, anti-inflammatory activity of SMP was evaluated by lipopolysaccharide (LPS) induced RAW264.7 cells. The release of nitric oxide (NO) was screened by Griess assay, and NF-κB p65 and NLRP3 proteins expression was examined by immunofluorescence assay. Then, the levels of creatinine (Cr), blood urea nitrogen (BUN), and uric acid (UA) were detected in mice induced by potassium oxonate, and the paw oedema, inflammatory mediators, and histolog...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Letter to the Editor Source Type: research
Title: Gout in the FootCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 8/1/2019 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news
AbstractObjectiveFew studies have systematically and quantitatively addressed the impact of urate ‐lowering therapy on monosodium urate (MSU) deposition. Herein, we analyzed the effect of lifestyle measures and conventional uric acid lowering therapy on MSU deposits in gout patients.MethodsIn this prospective study, subjects with a diagnosis of gout according to ACR/EULAR classification criteria and presence of MSU deposits in dual energy computed tomography (DECT) scans received either lifestyle intervention or conventional urate ‐lowering therapy for a mean period of 18 months before follow‐up DECT scan. Detected M...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Abstract Inflammasomes are a multi-protein platform forming a part of the innate immune system. Inflammasomes are at standby status and can be activated when needed. Inflammasome activation is an important mechanism for the production of active interleukin (IL)-1β and IL-18, which have important roles to instruct adaptive immunity. Active forms of inflammasomes trigger a series of inflammatory cascades and lead to the differentiation and polarization of naïve T cells and secretion of various cytokines, which can induce various kinds of autoimmune and rheumatic diseases such as systemic lupus erythematosu...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Publication date: Available online 14 July 2019Source: Pharmacological ResearchAuthor(s): Federica Raucci, Asif J. Iqbal, Anella Saviano, Paola Minosi, Marialuisa Piccolo, Carlo Irace, Francesco Caso, Raffaele Scarpa, Stefano Pieretti, Nicola Mascolo, Francesco MaioneAbstractGout is a paradigm of acute, self-limiting inflammation caused by the deposition of monosodium urate (MSU) crystals within intra-and/or peri-articular areas, which leads to excruciating pain, joint swelling and stiffness. The infiltration of leukocytes drives the inflammatory response and remains an attractive target for therapeutic intervention. In th...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
MONDAY, July 15, 2019 -- More than one-fourth of patients with acute gout discharged from the emergency department receive an opioid prescription, according to a study published online July 2 in Arthritis Care&Research. Deepan S. Dalal, M.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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