Mass Spectrometry-Based Non-targeted Metabolic Profiling for Disease Detection: Recent Developments

This article describes recent developments in MS-based non-targeted metabolomics research with applications to the detection of several major common human diseases, focusing on study cohorts, MS platforms utilized, statistical analyses and discriminant metabolite identification. Potential disease biomarkers recently discovered for type 2 diabetes, cardiovascular disease, hepatocellular carcinoma, breast cancer and prostate cancer through metabolomics are summarized, and limitations are discussed.
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research