Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus

Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Wenya Feng, Chunmei Chen, Shuyuan Mo, Changxing Qi, Jiaojiao Gong, Xiao-Nian Li, Qun Zhou, Yuan Zhou, Dongyan Li, Yongji Lai, Hucheng Zhu, Jianping Wang, Yonghui ZhangAbstractEleven highly oxygenated meroterpenoids, named terreustoxins A−K, along with five known analogues, were isolated from the Antarctic fungus Aspergillus terreus. The structures and absolute configurations of these undescribed compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Terreustoxins A−D are the first examples of meroterpenoids with two ortho-hydroxy groups at C-6 and C-7 in the terretonins family. Terreustoxin C and terretonin inhibited the proliferation of Con A-induced murine T cells at the concentration of 10 μM.Graphical abstract

Source: Phytochemistry - June 1, 2019 Category: Chemistry Source Type: research